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Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates.
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Conjugation note: Unconjugated Application note: WB Reactivity note: Human,Mouse,Rat
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Image Search Results
Journal: Frontiers in Endocrinology
Article Title: Functional analysis of fibroblasts and macrophages in head and neck paragangliomas
doi: 10.3389/fendo.2024.1397839
Figure Lengend Snippet: Expression of markers on fibroblasts derived from head and neck paraganglioma (HNPGN). Expression on fibroblast associated markers were examined by fibroblasts cultured from HNPGN using flow cytometry. (A) The sequential gating strategy is illustrated based on forward scatter and side scatter (left panel), exclusion of doublets (middle panel) and exclusion of dead cells (Fixable viability stain 575V negative population, right panel). (B) Illustrative histogram plots depicting the expression of CD90, PDPN and FAP (pink histograms). Dashed histograms show staining with isotype control antibodies. (C) Illustrative histogram plots showing the expression of MCT1 and MCT4 (pink histograms). (D) Illustrative histogram plots showing expression of CD220 AND CD222 (pink histograms). Dashed histograms depict staining with isotype control antibodies. Representative of fibroblasts from three different HNPGN samples.
Article Snippet: Staining was also performed with MCT1 (Rabbit polyclonal, Bethyl), MCT4 (D-1, Santa Cruz),
Techniques: Expressing, Derivative Assay, Cell Culture, Flow Cytometry, Staining, Control